CL 82198 hydrochloride
Chemical Name: N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide hydrochloride
Purity: ≥98%
Biological Activity
CL 82198 hydrochloride is a selective inhibitor of MMP-13 (89% inhibition at 10 μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75. Rescues paclitaxel induced axon degradation and reduces associated neurotoxicity in zebrafish.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design.
Chen et al.
J.Am.Chem.Soc., 2000;122:9648 -
IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75.
Borg et al.
Endocrine Abstr., 2003;5:122 -
PacT.-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish.
Lisse et al.
Proc Natl Acad Sci U S A, 2016;113:E2189
Product Datasheets
Citations for CL 82198 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for CL 82198 hydrochloride include:
3 Citations: Showing 1 - 3
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PacT.-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish.
Authors: Lisse Et al.
Proc Natl Acad Sci U S A 2016;113:E2189
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MMP13 is a critical target gene during the progression of osteoarthritis.
Authors: Wang Et al.
J Neurosci 2013;15:R5
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MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation.
Authors: Meierjohann Et al.
Mol Cancer 2010;9:201
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