Cl-4AS-1
Chemical Name: (4aα,4bβ,6aα,7α,9aβ,9bα,11aβ)-N-(2-Chlorophenyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1,4,6a-trimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide
Purity: ≥99%
Biological Activity
Cl-4AS-1 is a potent steroidal androgen receptor agonist (IC50 = 12 nM). Mimics the action of 5α-dihydrotestosterone (DHT). Transactivates the mouse mammary tumor virus (MMTV) promoter; represses MMP1 promoter activity. Inhibits 5α-reductase type I and II (IC50 values are 6 and 10 nM respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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4-Methyl-3-oxo-4-aza-5α-androst-1-ene-17β-N-aryl-carboxamides: an approach to combined androgen blockade [5α-reductase inhibition with androgen receptor binding in vitro].
Tolman et al.
J.Steroid.Biochem.Mol.Biol., 1997;60:303 -
Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands.
Schmidt et al.
J.Biol.Chem., 2009;284:36367
Product Datasheets
Citation for Cl-4AS-1
The citations listed below are publications that use Tocris products. Selected citations for Cl-4AS-1 include:
1 Citation: Showing 1 - 1
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Cell-Based Bioassay to Screen Environmental Chemicals and Human Serum for Total Glucocorticogenic Activity.
Authors: Sarah I Et al.
Environ Toxicol Chem 2021;40:177-186
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