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CK 666

Catalog #: 3950
26 Citations Datasheet
Catalog # Availability Size / Price Qty
3950/10
3950/50
CK 666 | CAS No. 442633-00-3 | Actin-related Products
1 Image
Description: Arp2/3 inhibitor; inhibits actin polymerization

Chemical Name: 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide

Purity: ≥99%

Product Details
Citations (26)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CK 666 is an inhibitor of the Arp2/3 complex; inhibits actin polymerization (IC50 = 4 μM).

Technical Data

M.Wt:
296.34
Formula:
C18H17FN2O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
442633-00-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Characterization of two classes of small molecule inhibitors of Arp2/3 complex.
    Nolen et al.
    Nature, 2009;460:1031
  2. X-ray crystal structures and molecular mechanism of improved Arp2/3 complex inhibitors.
    Han and Nolen
    1751 ACSB 2009 Abstracts. American Society for Cel, 2009;

Product Datasheets

Citations for CK 666

The citations listed below are publications that use Tocris products. Selected citations for CK 666 include:

26 Citations: Showing 1 - 10

  1. Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters.
    Authors: Jacob Et al.
    EMBO J  2023;42:e112030
  2. Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model.
    Authors: Raymond P Et al.
    J Virus Erad  2022;8:100307
  3. Nuclear F-actin and Lamin A antagonistically modulate nuclear shape.
    Authors: Daniel L Et al.
    J Cell Sci  2022;135
  4. Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms.
    Authors: Kurt I Et al.
    Cell Rep  2021;34:108750
  5. Melanoma cells adopt features of both mesenchymal and amoeboid migration within confining channels.
    Authors: Jeremy S Et al.
    Sci Rep  2021;11:17804
  6. Rac and Arp2/3-Nucleated Actin Networks Antagonize Rho During Mitotic and Meiotic Cleavages.
    Authors: Charles B Et al.
    Front Cell Dev Biol  2020;8:591141
  7. Mechanism of Long-Range Chromosome Motion Triggered by Gene Activation.
    Authors: William M Et al.
    Dev Cell  2020;52:309-320.e5
  8. Wiskott-Aldrich syndrome protein restricts cGAS/STING activation by dsDNA immune complexes.
    Authors: Philippe Et al.
    JCI Insight  2020;5
  9. Wound Healing Coordinates Actin Architectures to Regulate Mechanical Work.
    Authors: Visar Et al.
    Nat Phys  2020;15:696-705
  10. Macropinocytosis Overcomes Directional Bias in Dendritic Cells Due to Hydraulic Resistance and Facilitates Space Exploration.
    Authors: Matthieu Et al.
    Dev Cell  2019;49:171-188.e5
  11. Cytoskeletal polarization and cytokinetic signaling drives polar lobe formation in spiralian embryos.
    Authors: Charles B Et al.
    Dev Biol  2019;456:201-211
  12. Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization.
    Authors: Roesler Et al.
    Front Cell Neurosci  2019;13:330
  13. Bimodal sensing of guidance cues in mechanically distinct microenvironments.
    Authors: Tabdanov Et al.
    Nat Commun  2018;9:4891
  14. Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo.
    Authors: Yamagashi Et al.
    Biochem Biophys Res Commun  2018;496:834
  15. Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryo.
    Authors: Sepúlveda-Ramírez Et al.
    Dev Biol  2018;437:140
  16. c-Src activity is differentially required by cancer cell motility modes.
    Authors: Logue Et al.
    Oncogene  2018;37:2104
  17. Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry.
    Authors: Casper C Et al.
    Curr Biol  2018;28:2081-2093.e6
  18. Microtubule-Actomyosin Mechanical Cooperation during Contact Guidance Sensing.
    Authors: Tabdanov Et al.
    Cell Rep  2018;25:328
  19. αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin.
    Authors: Bharadwaj
    Nat Commun  2017;8:14348
  20. Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation
    Authors: Han Et al.
    Nature  2016;539:570
  21. Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral Amygdala.
    Authors: Basu Et al.
    Eneuro  2016;3
  22. Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body.
    Authors: Panousopoulou Et al.
    J Cell Sci  2016;129:1915
  23. Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement.
    Authors: Sorce Et al.
    Cell Calcium  2015;6:8872
  24. ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.
    Authors: Tornavaca Et al.
    Proc Natl Acad Sci U S A  2015;208:821
  25. Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest.
    Authors: Moreau Et al.
    Nat Commun  2015;112:12151
  26. Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte.
    Authors: Dalton and Carroll
    J Cell Sci  2013;126:2955

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