cis-VZ 185

Catalog #: 6939 Datasheet

Catalog #	Availability	Size / Price	Qty
6939/5

cis-VZ 185 | CAS No. 2306193-98-4 | Active Degrader Negative Controls

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Description: Negative control for VZ 185 (Cat. No. 6936)

Chemical Name: (2S,4S)-N-(2-((5-(4-(2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)piperazin-1-yl)pentyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide

Purity: ≥95%

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

cis-VZ 185 is a negative control for VZ 185 (Cat. No. 6936).

Technical Data

M.Wt:

995.23

Formula:

C₅₃H₆₇FN₈O₈S

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

2306193-98-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold under licence from the University of Dundee.

Background References

Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast, and selective von Hippel-Lindau (VHL) based dual degrader probe of BRD9 and BRD7.
Zoppi et al.
J.Med.Chem., 2019;62:699

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