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cis MZ 1

Catalog #: 6155
1 Citation Datasheet
Catalog # Availability Size / Price Qty
6155/5
cis MZ 1 | CAS No. 1797406-72-4 | Active Degrader Negative Controls
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Description: Negative Control for MZ 1 (Cat. No. 6154)

Chemical Name: (2S,4S)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

cis MZ 1 is a negative Control for MZ1 (Cat.No. 6154). Exhibits no significant VHL binding affinity.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MZ 1 is reviewed on the chemical probes website.

Technical Data

M.Wt:
1002.64
Formula:
C49H60ClN9O8S2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1797406-72-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under licence from the University of Dundee

Background References

  1. Selective small molecule induced degradation of the BET bromodomain protein BRD4.
    Zengerle et al.
    ACS Chem.Biol., 2015;10:1770

Product Datasheets

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Citation for cis MZ 1

The citations listed below are publications that use Tocris products. Selected citations for cis MZ 1 include:

1 Citation: Showing 1 - 1

  1. Activity of BET-proteolysis targeting chimeric (PROTAC) compounds in triple negative breast cancer.
    Authors: Noblejas-Lopez Et al.
    J Exp Clin Cancer Res  2019;38:383

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