Cinacalcet hydrochloride
Chemical Name: N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride
Purity: ≥98%
Biological Activity
Cinacalcet hydrochloride is a calcium-sensing receptor (CaSR) allosteric agonist. Activates CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays. Reduces serum parathyroid hormone levels in rats. Also potent CYP2D2 inhibitor (IC50 = 87 nM) and L-type calcium channel blocker. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor.
Ma et al.
J.Pharmacol.Exp.Ther., 2011;337:275 -
The calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism.
Goodman et al.
J.Am.Soc.Nephrol., 2002;13:1017
Product Datasheets
Citations for Cinacalcet hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Cinacalcet hydrochloride include:
2 Citations: Showing 1 - 2
-
Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation.
Authors: Ian P Et al.
Cell Signal 2023;107:110676
-
Area Postrema Cell Types that Mediate Nausea-Associated Behaviors.
Authors: Stephen D Et al.
Neuron 2021;109:461-472.e5
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Cinacalcet hydrochloride
There are currently no reviews for this product. Be the first to review Cinacalcet hydrochloride and earn rewards!
Have you used Cinacalcet hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
