Cilnidipine
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
Purity: ≥99%
Biological Activity
Cilnidipine is a dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine.
Murai et al.
Brain Res., 2000;854:6 -
Neuroprotective effects of a dual L/N-type Ca2+ channel blocker cilnidipine in the rat focal brain ischemia model.
Takahara et al.
Biol.Pharm.Bull., 2004;27:1388 -
The evaluation of the N-type channel blocking properties of cilnidipine and other voltage-dependent calcium antagonists.
Nap et al.
Fund.Clin.Pharmacol., 2004;18:309
Product Datasheets
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