Cilengitide

Catalog #: 5870
6 Citations Datasheet

Catalog #	Availability	Size / Price	Qty
5870/10

1 Image

Description: Potent and selective inhibitor of integrins αvβ3 and αvβ5

Alternative Names: EMD121974

Purity: ≥95%

View All Products for Integrin Receptor Inhibitors

Product Details

Citations (6)

Supplemental Products

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Cilengitide is a potent and selective inhibitor of integrins α_vβ₃ and α_vβ₅ (IC₅₀ values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.

Technical Data

M.Wt:

588.66

Formula:

C₂₇H₄₀N₈O₇

Sequence:

RGDFV

(Modifications: Phe-4 = D-Phe, Val-5 = Me-Val, Cyclized)

Solubility:

Soluble to 10 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

188968-51-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

The integrin antagonist cilengitide activates α_vβ₃, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells.
Alghisi et al.
PLoS One, 2009;4:e4449
CYR61 and α_vβ₅ integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma.
Monnier et al.
Cancer Res., 2008;68:7323

Product Datasheets

COA view current batch

Or select another batch:

View Batch

SDS

Citations for Cilengitide

The citations listed below are publications that use Tocris products. Selected citations for Cilengitide include:

6 Citations: Showing 1 - 6

Integrins Bidirectionally Regulate the Efficacy of Inhibitory Synaptic Transmission and Control GABAergic Plasticity.
Authors: Jerzy W Et al.
J Neurosci 2022;42:5830-5842
G protein-coupled receptor kinase phosphorylation of distal C-tail sites specifies βarrestin1-mediated signaling by chemokine receptor CXCR4.
Authors: Adriano Et al.
J Biol Chem 2022;298:102351
Extracorporeal shock waves protect cardiomyocytes from DOX-induced cardiomyopathy by upregulating survivin via the integrin-ILK-Akt-Sp1/p53 axis.
Authors: Lee Et al.
Sci Rep 2019;9:12149
Activation of αvβ3 Integrin Alters Fibronectin Fibril Formation in Human Trabecular Meshwork Cells in a ROCK-Independent Manner.
Authors: Filla Et al.
Invest Ophthalmol Vis Sci 2019;60:3897
Subendothelial matrix components influence endothelial cell apoptosis in vitro.
Authors: Elazer R Et al.
Am J Physiol Cell Physiol 2019;316:C210-C222
Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation.
Authors: Albarrán-Juárez Et al.
J Exp Med 2018;215:2655

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Reviews for Cilengitide

There are currently no reviews for this product. Be the first to review Cilengitide and earn rewards!

Have you used Cilengitide?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.