CHDI 113
Chemical Name: 5-[(3R)-3-(Cyclopropylamino)-1-pyrrolidinyl]-N-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-2-pyrazinecarboxamide
Purity: ≥98%
Biological Activity
CHDI 113 is a potent huntingtin (HTT) pre-mRNA splicing modulator (EC50 = 66 nM). It lowers HTT protein in both human Huntington's disease (HD) stem cells and in the brain of BACHD (bacterial artificial chromosome-mediated transgenic) mouse model. CHDI 113 is brain penetrant and orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Product Datasheets
Citation for CHDI 113
The citations listed below are publications that use Tocris products. Selected citations for CHDI 113 include:
1 Citation: Showing 1 - 1
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Identification and optimization of RNA-splicing modulators as Huntingtin protein-lowering agents for the treatment of Huntington's disease.
Authors: Liu Et al.
J.Med.Chem. 2024;66:13205
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