Home / Class II Histone Deacetylases Inhibitors / CHDI 00484077

CHDI 00484077

Catalog #: 7879 Datasheet
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7879/5
CHDI 00484077 | CAS No. 3025894-92-9 | Class II Histone Deacetylases Inhibitors
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Description: Potent and selective HDAC class IIa inhibitor

Chemical Name: N-((R)-1-((S)-2-Methylpyrrolidin-1-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide

Purity: ≥98%

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Biological Activity

CHDI 00484077 is a potent and selective class IIa histone deacetylase HDAC inhibitor (IC50 values = 10-30 nM in vivo, 0.01 nM and 0.04 nM in HEK293 and Jurkat cells, respectively). Exhibits 150-fold selectivity for class IIa over class I/IIb HDACs in cells. Orally bioavailable and CNS penetrant.

Technical Data

M.Wt:
382.39
Formula:
C18H21F3N4O2
Solubility:
Soluble to 100 mM in DMSO with gentle warming and to 100 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
3025894-92-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from CHDI Foundation

Product Datasheets

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