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CGP 71683 hydrochloride

Catalog #: 2199
6 Citations Datasheet
Catalog # Availability Size / Price Qty
2199/10
2199/50
CGP 71683 hydrochloride | CAS No. 192322-50-2 | NPY Receptor Antagonists
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Description: Highly selective and potent non-peptide NPY Y5 receptor antagonist

Chemical Name: N-[[trans-4-[[(4-Amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-1-naphthalenesulfonamide hydrochloride

Purity: ≥98%

Product Details
Citations (6)
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Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CGP 71683 hydrochloride is an extremely selective, non-peptide NPY Y5 receptor antagonist. Displays > 1000-fold selectivity over Y1, Y2 and Y4 receptors; IC50 values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y5, Y1, Y2 and Y4 receptors respectively. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats.

Technical Data

M.Wt:
512.07
Formula:
C26H29N5O2S.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
192322-50-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats.
    Reidelberger, Roger, Haver, Alvin, Chelikani, Prasanth
    Am J Physiol Endocrinol Metab, 2013;304(9):E944-50.
  2. Neuropeptide Y receptor Y5 as an inducible pro-survival factor in neuroblastoma: implications for tumor chemoresistance.
    Czarnecka M, Trinh E, Lu C, Kuan-Celarier A, Galli S, Hong S, Tilan J, Talisman N, Izycka-Swieszewska E, Tsuei J, Yang C, Martin S, Horton M, Christian D, Everhart L, Maheswaran I, Kitlinska J
    Oncogene, 2015;34(24):3131-43.
  3. Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor.
    Criscione et al.
    J.Clin.Invest., 1998;102:2136
  4. Potent and selective tools to investigate neuropeptide Y receptors in the central and peripheral nervous systems: BIB03304 (Y1) and CGP71683A (Y5).
    Dumont et al.
    Can.J.Physiol.Pharmacol., 2000;78:116
  5. Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig.
    Lecklin et al.
    Br.J.Pharmacol., 2002;135:2029

Product Datasheets

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Citations for CGP 71683 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for CGP 71683 hydrochloride include:

6 Citations: Showing 1 - 6

  1. Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects.
    Authors: Tilan Et al.
    Oncotarget  2013;4:2487
  2. Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats.
    Authors: Reidelberger Et al.
    Am J Physiol Endocrinol Metab  2013;304:E944
  3. Stress hormone epinephrine enhances adipogenesis in murine embryonic stem cells by up-regulating the neuropeptide Y system.
    Authors: Han Et al.
    PLoS One  2012;7:e36609
  4. Deconstruction of a neural circuit for hunger.
    Authors: Atasoy Et al.
    Am J Physiol Cell Physiol  2012;488:172
  5. Neuropeptide Y inhibits cholangiocarcinoma cell growth and invasion.
    Authors: Demorrow Et al.
    Nature  2011;300:C1078
  6. Dipeptidyl peptidases as survival factors in Ewing sarcoma family of tumors: implications for tumor biology and therapy.
    Authors: Lu Et al.
    J Biol Chem  2011;286:27494

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