CGP 3466B maleate
Chemical Name: N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)amine maleate
Purity: ≥99%
Biological Activity
CGP 3466B maleate is an orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. Exhibits antiapoptotic activity via inhibition of GAPDH nuclear translocation and mitochondrial complex 1-dependent H2O2 release. CGP 3466B inhibits colon cancer proliferation in vitro and displays neuroprotective activity in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade.
Guha P, Harraz M, Snyder S
Proc Natl Acad Sci U S A, 2016;113(5):1417-22. -
TCH346 prevents motor symptoms and loss of striatal FDOPA uptake in bilaterally MPTP-treated primates.
Andringa et al.
Neurobiol.Dis., 2003;14:205 -
An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease.
Sagot et al.
Br.J.Pharmacol., 2000;131:721 -
Clorgyline and other propargylamine derivatives as inhibitors of succinate-dependent H2O2 release at NADH:UBIQUINONE oxidoreductase (Complex I) in brain mitochondria.
Zoccarato et al.
J.Bioenerg.Biomembr., 2008;40:289
Product Datasheets
Citation for CGP 3466B maleate
The citations listed below are publications that use Tocris products. Selected citations for CGP 3466B maleate include:
1 Citation: Showing 1 - 1
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Behavioral effects of cocaine mediated by nitric oxide-GAPDH transcriptional signaling.
Authors: Xu Et al.
Neuron 2013;78:623
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