CC 401 dihydrochloride
Chemical Name: 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole dihydrochloride
Purity: ≥98%
Biological Activity
CC 401 dihydrochloride is a high affinity JNK inhibitor (Ki values are 25-50 nM). Inhibits JNK via competitive binding of the ATP-binding site of active, phosphorylated JNK. Exhibits > 40-fold selectivity for JNK over p38, ERK, IKK2, protein kinase C, Lck and ZAP70. Hepatoprotective. Also inhibits HCMV replication.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The c-Jun N-terminal kinase inhibitor SP600125 inhibits human cytomegalovirus replication.
Zhang et al.
J.Med.Virol., 2015;87:2135 -
Inhibition of JNK sensitizes hypoxic colon cancer cells to DNA-damaging agents.
Vasilevskaya et al.
Clin.Cancer.Res., 2015;21:4143 -
c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation.
Uehara et al.
Transplantation., 2004;78:324 -
JNK mediates hepatic ischemia reperfusion injury.
Uehara et al.
J.Hepatol., 2005;42:850 -
A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis.
Ma et al.
J.Am.Soc.Nephrol., 2007;18:472 -
Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat.
Ma et al.
Lab.Invest., 2009;89:470
Product Datasheets
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