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CBR-470-1

Catalog #: 7018 Datasheet
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7018/50
7018/10
CBR-470-1 | CAS No. 2416095-06-0 | Nrf2 Activators
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Description: PGK1 inhibitor; activates Nrf2

Chemical Name: (3R,4S)-rel-4-[(4-Chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-3-thiophenamine-1,1-dioxide

Purity: ≥98%

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Biological Activity

CBR-470-1 is a phosphoglycerate kinase 1 (PGK1) inhibitor. CBR-470-1 promotes accumulation of the reactive metabolites methylglyoxal (MGO) resulting in KEAP1 modification and dimerization, which in turn leads to activation of the Nrf2 transcriptional program. CBR-470-1 protects SH-SY5Y neuroblastoma cells from MPP+-induced cytotoxicity via the Keap1-Nrf2 cascade.

Technical Data

M.Wt:
365.89
Formula:
C14H20ClNO4S2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2416095-06-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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