CASIN

Catalog #: 5050
2 Citations Datasheet

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5050/10

CASIN | CAS No. 425399-05-9 | Rho GTPase Inhibitors

1 Image

Description: Cdc42 inhibitor

Chemical Name: 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol

Purity: ≥98%

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Product Details

Citations (2)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CASIN is a Cdc42 GTPase inhibitor (IC₅₀ = 2 μM). Reduces active levels of Cdc42 in aged hematopoietic stem cells (HSCs) to that in young HSCs. Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo. Increases histone H4K16 acetylation in aged HSCs.

Technical Data

M.Wt:

306.4

Formula:

C₂₀H₂₂N₂O

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

425399-05-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Chemical approaches to stem cell biology and therapeutics.
Li et al.
Cell Stem Cell, 2013;13:270
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.
Florian et al.
Cell Stem Cell, 2012;10:520
Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components.
Peterson et al.
Chem.Biol., 2006;13:443
Concerted regulation of actin polymerization during constitutive secretion by Cortactin and PKD2
F Weeber, A Becher, T Seibold, T Seufferlei, T Eiseler
J. Cell. Sci., 2019;0(0):.

Product Datasheets

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Citations for CASIN

The citations listed below are publications that use Tocris products. Selected citations for CASIN include:

2 Citations: Showing 1 - 2

Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model.
Authors: Raymond P Et al.
J Virus Erad 2022;8:100307
Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel.
Authors: Cheng Et al.
FEBS Lett 2011;585:328

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