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Carvedilol

Catalog #: 2685
3 Citations Datasheet
Catalog # Availability Size / Price Qty
2685/50
Carvedilol | CAS No. 72956-09-3 | Non-selective Adrenergic beta Receptor Antagonists
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Description: Potent and non-selective β antagonist; also potent α1 antagonist
Alternative Names: BM 14190

Chemical Name: 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Carvedilol is a potent β-adrenoceptor and α1-adrenoceptor antagonist (Ki values are 0.81, 0.96 and 2.2 nM for β1-, β2- and α1-adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K+ (KIR) channels, voltage-dependent Ca2+ channels and exhibits antioxidant properties at higher concentrations.

Technical Data

M.Wt:
406.47
Formula:
C24H26N2O4
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
72956-09-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Use of non-selective ?-blockers is associated with decreased tumor proliferative indices in early stage breast cancer
    A Montoya, CN Amaya, A Belmont, N Diab, R Trevino, G Villanueva, S Rains, LA Sanchez, N Badri, S Otoukesh, A Khammanivo, D Liss, ST Baca, RJ Aguilera, EB Dickerson, A Torabi, AK Dwivedi, A Abbas, K Chambers, BA Bryan, Z Nahleh
    Oncotarget, 2017;8(4):6446-6460.
  2. Carvedilol blocks cardiac KATP and KG but not IK1 channels by acting at the bundle-crossing region.
    Kikuta et al.
    Eur.J.Pharmacol., 2006;529:47
  3. Differential effects of bucindolol and carve. on noradrenaline-induced hypertonic response in ventricular cardiomyocytes of adult rats.
    Ponicke et al.
    J.Pharmacol.Exp.Ther., 2002;301:71

Product Datasheets

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Citations for Carvedilol

The citations listed below are publications that use Tocris products. Selected citations for Carvedilol include:

3 Citations: Showing 1 - 3

  1. Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion.
    Authors: Zaytseva Et al.
    Sens Actuators B Chem  2013;188
  2. Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.
    Authors: Baker Et al.
    FASEB J  2011;25:4486
  3. Blockade of adrenoreceptors inhibits the splenic response to stroke.
    Authors: Ajmo Et al.
    Nat Commun  2009;218:47

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