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Carbenoxolone disodium

Catalog #: 3096
5 Citations Datasheet
Catalog # Availability Size / Price Qty
3096/50
Carbenoxolone disodium | CAS No. 7421-40-1 | Gap Channel Blockers
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Description: Gap junction blocker. Also inhibitor of 11 β-hydroxysteroid dehydrogenase

Chemical Name: (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid disodium

Purity: ≥98%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.

Technical Data

M.Wt:
614.72
Formula:
C34H48Na2O7
Solubility:
Soluble to 100 mM in water
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
7421-40-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Role of retinal pigment epithelial cell beta-catenin signaling in experimental proliferative vitreoretinopathy.
    Umazume K, Tsukahara R, Liu L, Fernandez de Castro J, McDonald K, Kaplan H, Tamiya S
    Am J Pathol, 2014;184(5):1419-28.
  2. Differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues.
    Jellinck et al.
    J.Steroid Biochem.Mol.Biol., 1993;46:209
  3. Carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase A-dependent pathway.
    Sagar and Larson
    J.Cell.Biochem., 2006;98:1543

Product Datasheets

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Citations for Carbenoxolone disodium

The citations listed below are publications that use Tocris products. Selected citations for Carbenoxolone disodium include:

5 Citations: Showing 1 - 5

  1. Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis.
    Authors: Ferlauto Et al.
    Nat Commun  2018;9:992
  2. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
    Authors: Chai Et al.
    Neuron  2017;95:531
  3. Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles.
    Authors: Shuhaibar Et al.
    Proc Natl Acad Sci U S A  2015;112:5527
  4. Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism.
    Authors: Bhaskaracharya Et al.
    PLoS One  2014;9:e93058
  5. Dominance of flow-mediated constriction over flow-mediated dilatation in the rat carotid artery.
    Authors: Craig and Martin
    Br J Pharmacol  2012;167:527

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