Carbamazepine

Biological Activity

Carbamazepine is an inhibitor of neuronal voltage-gated Na⁺ channels. Exhibits anticonvulsant activity. Potentiates GABA-induced Cl^- currents in HEK 293 cells expressing the GABA_A receptor α1β2γ2 subtype combination. Can induce autophagy by inhibiting inositol synthesis. Also delays disease onset and prolongs survival in a mouse amyotrophic lateral sclerosis (ALS) model, as well as reducing motor neuron loss and altered muscle morphology.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
   Galluzzi et al.
   Nat.Rev.Drug.Discov., 2017;
2. Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore.
   Lipkind and Fozzard
   Mol.Pharmacol., 2010;78:631
3. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.
   Sarkar et al.
   Cell Death Differ., 2009;16:46
4. Repurposing carbamaz. for the treatment of amyotrophic lateral sclerosis in SOD1-G93A mouse model.
   Zhang et al.
   CNS Neurosci.Ther., 2018;24:1163
5. Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamaz. and phen.
   Granger et al.
   Mol.Pharmacol., 1995;47:1189
6. Lamotrigine and carbamaz. affect differently the release of D-[³H] aspartate from mouse cerebral cortex slices: involvement of NO.
   Afanas'ev et al.
   Neurochem.Res., 1999;24:1153

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