Canertinib dihydrochloride

Catalog #: 5916 Datasheet

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Canertinib dihydrochloride | CAS No. 289499-45-2 | EGF Receptor Inhibitors

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Description: Potent EGFR kinase inhibitor

Alternative Names: CI 1033,PD 183805

Chemical Name: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride

Purity: ≥98%

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Canertinib dihydrochloride is a potent EGFR kinase inhibitor (IC₅₀ = 7.4 nM). Blocks autophosphorylation of erbB2. Inhibits growth of A431 tumor xenografts in mice. Cell permeable.

Technical Data

M.Wt:

558.86

Formula:

C₂₄H₂₅ClFN₅O_3.2HCl

Solubility:

Soluble to 20 mM in water and to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

289499-45-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold for research purposes under agreement from Pfizer Inc.

Background References

Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions.
Smaill et al.
J.Med.Chem., 2000;43:1380

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