Camptothecin
Chemical Name: (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Purity: ≥98%
Biological Activity
Camptothecin is a cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor. Induces single strand DNA breaks and protein-DNA crosslinks.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
DNA topoisomerase poisons as antitumour drugs.
Liu
Annu.Rev.Biochem, 1989;58:351 -
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
Hsiang et al.
J.Biol.Chem., 1985;260:14873 -
Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro.
Pantazis et al.
Int.J.Cancer, 1993;53:863
Product Datasheets
Citations for Camptothecin
The citations listed below are publications that use Tocris products. Selected citations for Camptothecin include:
6 Citations: Showing 1 - 6
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Evaluation of an Aqueous Extract from Horseradish Root (Armoracia rusticana Radix) against Lipopolysaccharide-Induced Cellular Inflammation Reaction.
Authors: Herz Et al.
Evid Based Complement Alternat Med 2017;2017:1950692
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CLIC5: a novel ETV6 target gene in childhood acute lymphoblastic leukemia.
Authors: Neveu Et al.
Haematologica 2016;
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Preclinical evaluation of 4-methylthiobutyl isothiocyanate on liver cancer and cancer stem cells with different p53 status.
Authors: Lamy Et al.
PLoS One 2013;8:e70846
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Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism.
Authors: Gründemann Et al.
PLoS One 2013;8:e68016
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Immunosuppressive activity of an aqueous Viola tricolor herbal extract.
Authors: Hellinger Et al.
J Ethnopharmacol 2013;151:299
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Oxygen-sensitive {δ}-opioid receptor-regulated survival and death signals: novel insights into neuronal preconditioning and protection.
Authors: Ma Et al.
Sci Rep 2005;280:16208
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