Caffeine
Chemical Name: 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Purity: ≥99%
Biological Activity
Caffeine is a central nervous system stimulant. Antagonist at A1 and A2A adenosine receptors and inhibitor of cyclic nucleotide phosphodiesterases. Mobilizes calcium from intracellular stores and inhibits benzodiazepine binding to GABA receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects.
Nehlig et al.
Brain Res.Brain Res.Rev., 1992;17:139 -
Caffeine as a psychomotor stimulant: mechanism of action.
Fisone et al.
Cell.Mol.Life Sci., 2004;61:857 -
Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease.
Chen et al.
J.Neuroinflammation, 2008;5:12
Product Datasheets
Citations for Caffeine
The citations listed below are publications that use Tocris products. Selected citations for Caffeine include:
2 Citations: Showing 1 - 2
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Contrasting Effects of the Cytotoxic Anticancer Drug gemcit. and the EGFR Tyrosine Kinase Inhibitor gefi. on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells.
Authors: Okita Et al.
PLoS One 2015;10:e0139809
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Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes.
Authors: Seto Et al.
J Cell Sci 2013;8:e66404
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