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Cabergoline

Catalog #: 2664
4 Citations Datasheet
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2664/50
Cabergoline | CAS No. 81409-90-7 | Non-selective Dopamine Receptor Agonists
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Description: D2-like agonist (D2>D3>D4)

Chemical Name: N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8-carboxamide

Purity: ≥99%

Product Details
Citations (4)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Cabergoline is a selective D2-like dopamine receptor agonist (Ki values are 0.7, 1.5, 9.0 and 165 nM for D2, D3, D4 and D5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (Ki = 1.2 - 20.0 nM for 5-HT1A, 5-HT1D, 5-HT2A and 5-HT2B). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.

Technical Data

M.Wt:
451.6
Formula:
C26H37N5O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
81409-90-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effect of cabergoline, a DA agonist, on estrogen-induced rat pituitary tumors:in vitro culture studies.
    Eguchi et al.
    Endocr.J., 1995;42:413
  2. A review of the receptor-binding and pharmacokinetic properties of DA agonists.
    Kvernmo et al.
    Clin.Ther., 2006;28:1065
  3. Sustained caberg. treatment reverses levodopa-induced dyskinesias in parkinsonian monkeys.
    Hadj Tahar et al.
    Cin.Neuropharmacol., 2000;23:195

Product Datasheets

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Citations for Cabergoline

The citations listed below are publications that use Tocris products. Selected citations for Cabergoline include:

4 Citations: Showing 1 - 4

  1. Expression of Stem Cell Markers and DA D2 Receptors in Human and Rat Prolactinomas.
    Authors: Gao Et al.
    Med Sci Monit  2017;23:1827
  2. Activation of DRD5 inhibits tumor growth by autophagic cell death.
    Authors: Leng Et al.
    Autophagy  2017;13:1404
  3. Suppression of mTOR pathway and induction of autophagy-dependent cell death by caberg.
    Authors: Lin Et al.
    PLoS One  2015;6:39329
  4. Cabergoline, DA D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity.
    Authors: Odaka Et al.
    J Biol Chem  2014;9:e99271

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