Biological Activity
C 176 is a mSTING antagonist. Covalently binds Cys91 of mouse but not human STING. Blocks activation-induced palmitoylation of STING and formation of STING clusters. Reduces CMA (Cat. No. 6677) -induced increase in serum IFNs in vivo and suppresses systemic inflammation in a mouse inflammatory disease model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Targeting STING with covalent small-molecule inhibitors.
Haag et al.
Nature, 2018;559:269
Product Datasheets
Citation for C 176
The citations listed below are publications that use Tocris products. Selected citations for C 176 include:
1 Citation: Showing 1 - 1
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Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies.
Authors: Kevin C Et al.
J Exp Med 2023;220
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