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BX 430

Catalog #: 5545
2 Citations Datasheet
Catalog # Availability Size / Price Qty
5545/50
5545/10
BX 430 | CAS No. 688309-70-8 | P2X Receptor Antagonists
1 Image
Description: Selective P2X4 allosteric antagonist

Chemical Name: N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N'-(3-pyridinyl)urea

Purity: ≥99%

Product Details
Citations (2)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BX 430 is a selective P2X4 allosteric antagonist (IC50 = 0.54 μM). Exhibits >10-fold selectivity for human P2X4 receptors over P2X1, P2X2, P2X3, P2X5 and P2X7 receptors. Binds noncompetitively at extracellular allosteric site. Effective at human and zebrafish, but not mouse and rat P2X4 receptors.

Technical Data

M.Wt:
413.11
Formula:
C15H15Br2N3O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
688309-70-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A central role for P2X7 receptors in human microglia
    L Janks, CVR Sharma, TM Egan
    J Neuroinflammation, 2018;15(1):325.
  2. Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels
    Ase et al.
    Mol.Pharmacol., 2015;87:606

Product Datasheets

Citations for BX 430

The citations listed below are publications that use Tocris products. Selected citations for BX 430 include:

2 Citations: Showing 1 - 2

  1. Pharmacological and genetic characterisation of the canine P2X4 receptor.
    Authors: Belinda L Et al.
    Br J Pharmacol  2020;177:2812-2829
  2. HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells.
    Authors: Datta Et al.
    Front Cell Neurosci  2019;13:329

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