Bryostatin 1
Chemical Name: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E, 4E)-2,4-octadienoic acid ester
Purity: ≥98%
Biological Activity
Bryostatin 1 is a protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents. Restores hippocampal synapses and spatial learning and memory in an in vivo model of fragile X syndrome.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Bryostatin-1 restores hippocampal synapses and spatial learning and memory in adult fragile X mice.
Sun et al.
J Pharmacol Exp Ther., 2014;349:393 -
The catalytic domain of protein kinase Cδ confers protection from down-regulation induced by bryostatin 1.
Lorenzo et al.
J.Biol.Chem., 1997;272:33338 -
Bryostatin-1: pharmacology and therapeutic potential as a CNS drug.
Sun and Alkon
CNS Drug Rev., 2006;12:1 -
The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.
Wender et al.
Proc.Natl.Acad.Sci.USA, 1998;95:6624
Product Datasheets
Citations for Bryostatin 1
The citations listed below are publications that use Tocris products. Selected citations for Bryostatin 1 include:
6 Citations: Showing 1 - 6
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Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents.
Authors: Marsden
Virology 2018;520:83
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PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5.
Authors: Schaffer Et al.
Cell Rep 2018;25:2470
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Bryostatin-1 alleviates experimental multiple sclerosis.
Authors: Kornberg
Proc Natl Acad Sci U S A. 2018;115(9):2186
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Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
Authors: Park Et al.
Nat Immunol 2016;17:914
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Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
Authors: Visavadiya
Cell Communication and Signaling 2016;14:32
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Neuronal splicing regulator RBFOX3(NeuN) regulates adult hippocampal neurogenesis and synaptogenesis
Authors: Lin Et al.
PLoS One 2016;11:e0164164
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