BMS 688521
Chemical Name: 6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid
Purity: ≥98%
Biological Activity
BMS 688521 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 2.5 and 78 nM in HUVEC adhesion and mouse specific adhesion assays respectively). Inhibits eosinophil accumulation in the lungs in a mouse allergic eosinophilic lung inflammation model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
Product Datasheets
Citation for BMS 688521
The citations listed below are publications that use Tocris products. Selected citations for BMS 688521 include:
1 Citation: Showing 1 - 1
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CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells.
Authors: Jing Et al.
Cell Rep 2019;28:2892-2904.e7
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