BMS 345541
Chemical Name: N1-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride
Purity: ≥99%
Biological Activity
BMS 345541 is a selective allosteric inhibitor of IKK (IC50 values are 0.3 and 4.0 μM for IKKβ and IKKα respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NFκB dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size Specific
N Nishijima, T Hirai, K Misato, M Aoyama, E Kuroda, KJ Ishii, K Higashisak, Y Yoshioka, Y Tsutsumi
Front Immunol, 2017;8(0):379. -
Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IκB kinase through suppression of metalloproteinase expression.
Pattoli et al.
J.Pharmacol.Exp.Ther., 2005;315:382 -
BMS-345541 is a highly selective inhibitor of IκB kinase that binds at an allosteric site of the enzyme and blocks NF- κB-dependent transcription in mice.
Burke et al.
J.Biol.Chem., 2003;278:1450 -
Inhibition of choriodecidual cytokine production and inflammatory gene expression by selective IκB kinase (IKK) inhibitors.
De Silva et al.
Br.J.Pharmacol., 2010;160:1808
Product Datasheets
Citations for BMS 345541
The citations listed below are publications that use Tocris products. Selected citations for BMS 345541 include:
2 Citations: Showing 1 - 2
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Mechanistic Target of Rapamycin Complex 1 Signaling Modulates Vascular Endothelial Function Through Reactive Oxygen Species.
Authors: Reho Et al.
J Am Heart Assoc 2019;8:e010662
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Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING.
Authors: Michael Et al.
Mol Cell 2019;74:801-815.e6
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