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BMS 193885

Catalog #: 3242
1 Citation Datasheet
Catalog # Availability Size / Price Qty
3242/10
3242/50
BMS 193885 | CAS No. 679839-66-8 | NPY Receptor Antagonists
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Description: Potent, competitive NPY Y1 receptor antagonist

Chemical Name: 1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3,5-dimethyl ester L-Lactate

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BMS 193885 is a potent, competitive neuropeptide (NPY) Y1 antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. Reduces food intake and body weight via central Y1 inhibition and is brain penetrant.

Technical Data

M.Wt:
680.79
Formula:
C33H42N4O6.C3H6O3
Solubility:
Soluble to 20 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
679839-66-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Cardiovascular responses to chemical stimulation of the hypothalamic arcuate nucleus in the rat: role of the hypothalamic paraventricular nucleus.
    Kawabe, Tetsuya, Kawabe, Kazumi, Sapru, Hreday N
    PLoS ONE, 2012;7(9):e45180.
  2. Dihydropyridine neuropeptide Y Y1 receptor antagonists 2: bioisosteric urea replacements
    Poindexter et al.
    Bioorg.Med.Chem., 2004;12:507
  3. Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist
    Antal-Zimanyi et al.
    Eur.J.Pharmacol., 2008;590:224
  4. Dihydropyridine neuropeptide Y Y1 receptor antagonists.
    Poindexter et al.
    Bioorg.Med.Chem.Letts., 2002;12:379

Product Datasheets

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Citation for BMS 193885

The citations listed below are publications that use Tocris products. Selected citations for BMS 193885 include:

1 Citation: Showing 1 - 1

  1. Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch.
    Authors: Acton Et al.
    Cell Rep  2019;28:625

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