BMH 21
Chemical Name: N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
Purity: ≥98%
Biological Activity
BMH 21 is a p53 pathway activator; induces expression of p53 target genes. Also RNA polymerase 1 inhibitor; promotes degradation of RPA194. Reduces viability of multiple tumor cell lines and attenuates tumor growth of A375 melanoma cell xenografts in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.
Peltonen et al.
Cancer Cell, 2014;13:77 -
Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors.
Colis et al.
J.Med.Chem., 2014;57:4950 -
Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents.
Peltonen et al.
PLoS ONE, 2010;5:e12996
Product Datasheets
Citation for BMH 21
The citations listed below are publications that use Tocris products. Selected citations for BMH 21 include:
1 Citation: Showing 1 - 1
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Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction.
Authors: McCullough Et al.
Transl Psychiatry 2018;8:164
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