BIMU 8
Chemical Name: 2,3-Dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride
Purity: ≥98%
Biological Activity
BIMU 8 is a potent 5-HT4 receptor full agonist (KD = 77 nM and EC50 = 18 nM for wild type 5-HT4 receptors). Binds to receptors in a mechanism different to that of the endogenous ligand 5-HT.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrial functions
Sci Rep, 2016;6(0):37336. -
Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors.
Pellissier et al.
Mol.Pharmacol., 2009;75:982 -
Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: Indazole and benzimidazoline derivatives.
Schaus et al.
J.Med.Chem., 1998;41:1943
Product Datasheets
Citations for BIMU 8
The citations listed below are publications that use Tocris products. Selected citations for BIMU 8 include:
7 Citations: Showing 1 - 7
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Serotonin receptor 4 regulates hippocampal astrocyte morphology and function.
Authors: Daniel Et al.
Glia 2021;69:872-889
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The 5-HT4 receptor interacts with adhesion molecule L1 to modulate morphogenic signaling in neurons.
Authors: Andre Et al.
J Cell Sci 2021;134
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Respiratory depression and analgesia by opioid drugs in freely behaving larval zebrafish.
Authors: Carolina da Silveira Et al.
Elife 2021;10
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Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations.
Authors: James L Et al.
J Anim Sci 2018;96:1570-1578
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5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrialfunctions
Authors: Wang Et al.
Scientific Reports 2016;6:37336
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Genetic variation in HTR4 and lung function: GWAS follow-up in mouse.
Authors: House Et al.
PLoS One 2015;29:323
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Serotonin type 4 receptor dimers.
Authors: Lucie P Et al.
Methods Cell Biol 2013;117:123-39
FAQs
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