BIIE 0246 hydrochloride

Catalog #: 7377
2 Citations Datasheet

Catalog #	Availability	Size / Price	Qty
7377/10
7377/1

BIIE 0246 hydrochloride | CAS No. 246146-31-6 | NPY Receptor Antagonists

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Description: Potent, selective and competitive non-peptide NPY Y2 receptor antagonist; active in vivo

Alternative Names: BIIE 0246 2HCl,BIIE0246 2HCl

Chemical Name: N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide dihydrochloride

Purity: ≥98%

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Product Details

Citations (2)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BIIE 0246 hydrochloride is a potent, selective and competitive nonpeptide antagonist for the neuropeptide Y Y₂ receptor (IC₅₀ = 15 nM). Displays > 650-fold selectivity for NPY Y₂ over Y₁, Y₄ and Y₅ receptors. Active in vivo.

Technical Data

M.Wt:

968.98

Formula:

C₄₉H₅₇N₁₁O₆.2HCl

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

246146-31-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

BIIE0246: a selective and high affinity neuropeptide Y Y₂ receptor antagonist.
Doods et al.
Eur.J.Pharmacol., 1999;384:R3
BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y₂ receptor antagonist.
Dumont et al.
Br.J.Pharmacol., 2000;129:1075
Vascular pharmacology of BIIE0246, the first selective non-peptide neuropeptide Y Y₂ receptor antagonist, in vivo.
Malmstrom
Br.J.Pharmacol., 2001;133:1073

Product Datasheets

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Citations for BIIE 0246 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for BIIE 0246 hydrochloride include:

2 Citations: Showing 1 - 2

mTOR-neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain.
Authors: Yue Et al.
JCI Insight 2022;7
Photo-induced receptor confinement drives ligand-independent GPCR signaling.
Authors: Sanchez Et al.
Science 2021;371

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