BIBP 3226 trifluoroacetate

Catalog #: 2707
14 Citations Datasheet

Catalog #	Availability	Size / Price	Qty
2707/2

BIBP 3226 trifluoroacetate | NPY Receptor Antagonists

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Description: Mixed NPY Y1 and NPFF receptor antagonist

Chemical Name: N-[(1R)]-4-[(Aminoiminomethyl)amino-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl-α-phenylbenzeneacetamide trifluoroacetate

Purity: ≥98%

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Product Details

Citations (14)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BIBP 3226 trifluoroacetate is a mixed non-peptide neuropeptide Y Y₁ (NPY Y₁) and neuropeptide FF (NPFF) receptor antagonist (K_i values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y₁, hNPFF₂, rNPFF, rNPY Y₂, rNPY Y₄ and rNPY Y₅ respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.

Important Information

This product is sold as a TFA salt. The stoichiometry of the salt and hydration levels vary from batch to batch. This product is sold in gross weight with the batch specific Net Product Content (free base) available on the Certificate of Analysis

Technical Data

M. Wt

473.57 (Free Base)

Formula:

C₂₇H₃₁N₅O₃.xCF₃CO₂H

Solubility:

Soluble to 1 mg/ml in water and to 50 mg/ml in DMSO

Purity:

≥98%

Storage:

Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats.
Reidelberger, Roger, Haver, Alvin, Chelikani, Prasanth
Am J Physiol Endocrinol Metab, 2013;304(9):E944-50.
Neuropeptide y gates a stress-induced, long-lasting plasticity in the sympathetic nervous system.
Wang Q, Wang M, Whim M
J Neurosci, 0;33(31):12705-17.
Anxiogenic-like effect of the neuropeptide Y Y₁ receptor antagonist BIBP3226: antagonism with D.pam.
Kask et al.
Eur.J.Pharmacol., 1996;317:R3
Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226.
Mollereau et al.
Br.J.Pharmacol., 2001;133:1
In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist.
Fang et al.
Peptides, 2006;27:2207

Product Datasheets

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Citations for BIBP 3226 trifluoroacetate

The citations listed below are publications that use Tocris products. Selected citations for BIBP 3226 trifluoroacetate include:

14 Citations: Showing 1 - 10

Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch.
Authors: Acton Et al.
Cell Rep 2019;28:625
Platelet Lysate-Derived Neuropeptide y Influences Migration and Angiogenesis of Human Adipose Tissue-Derived Stromal Cells.
Authors: Businaro Et al.
Sci Rep 2018;8(1):14365
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience.
Authors: Ahsan Raza
Nat Commun 2017;8(1):189
Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro.
Authors: Martins Et al.
ASN Neuro 2015;7
NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking.
Authors: Pleil Et al.
Nat Neurosci 2015;18:545
Neuropeptide Y stimulates autophagy in hypothalamic neurons.
Authors: Aveleira Et al.
Cell Death Dis 2015;112:E1642
High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes.
Authors: Zacharia Et al.
PLoS One 2013;8:e65969
Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate.
Authors: Santos-Carvalho Et al.
Proc Natl Acad Sci U S A 2013;4:e636
Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats.
Authors: Reidelberger Et al.
Am J Physiol Endocrinol Metab 2013;304:E944
Pre-diabetes augments neuropeptide Y1- and α1-receptor control of basal hindlimb vascular tone in young ZDF rats.
Authors: Novielli Et al.
PLoS One 2012;7:e46659

Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice.
Authors: Pleil Et al.
Neuropharmacology 2012;62:1777

Glucocorticoid signaling in the arcuate nucleus modulates hepatic Ins sensitivity.
Authors: Yi Et al.
Diabetes 2012;61:339

Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors.
Authors: Sparrow Et al.
Proc Natl Acad Sci U S A 2012;37:1409

Involvement of neuropeptide Y and its Y1 and Y5 receptors in maintaining self-renewal and proliferation of human embryonic stem cells.
Authors: Son Et al.
J Cell Mol Med 2011;15:152

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