BC 11 hydrobromide

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases
   
   Cell Death Dis, 2016;7(12):e2565.
2. Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR) and concomitant activation of gelatinolytic enzymes.
   Magnussen S, Hadler-Olsen E, Latysheva N, Pirila E, Steigen S, Hanes R, Salo T, Winberg J, Uhlin-Hansen L, Svineng G
   PLoS ONE, 2014;9(8):e105929.
3. Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - ?1 (TGF-?1) and potential effects on migration and invasion
   SN Magnussen, E Hadler-Ols, DE Costea, E Berg, CC Jacobsen, B Mortensen, T Salo, I Martinez-Z, JO Winberg, L Uhlin-Hans, G Svineng
   BMC Cancer, 2017;17(1):350.
4. Elucidating novel urokinase-type plasminogen activator inhibitors.
   Smith et al.
   Int.Soc.Thromb.Haemost. (Abstract), 2011;9:819
5. Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells
   Longo et al.
   Molecules, 2015;20:9879

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