BAY 58-2667 hydrochloride
Chemical Name: 4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid hydrochloride
Purity: ≥98%
Biological Activity
BAY 58-2667 hydrochloride is a potent soluble guanylyl cyclase (sGC) activator (EC50 = 6.4 nM). Binds heme-free sGC. Exhibits antihypertensive effects in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle.
Stasch et al.
Br.J.Pharmacol., 2002;136:773 -
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels.
Stasch et al.
J.Clin.Invest., 2006;116:2552 -
Probing the presence of the ligand-binding haem in cellular nitric oxide receptors.
Roy et al.
Br.J.Pharmacol., 2008;153:1495
Product Datasheets
Citations for BAY 58-2667 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for BAY 58-2667 hydrochloride include:
2 Citations: Showing 1 - 2
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Modulation of soluble guanylate cyclase ameliorates pulmonary hypertension in a rat model of chronic thromboembolic pulmonary hypertension by stimulating angiogenesis.
Authors: John Et al.
Physiol Rep 2022;10:e15156
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Inhibition of MPO (Myeloperoxidase) Attenuates Endothelial Dysfunction in Mouse Models of Vascular Inflammation and Atherosclerosis.
Authors: Cheng Et al.
Arterioscler Thromb Vasc Biol 2019;:ATVBAHA119312725
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