BAY 41-2272
Chemical Name: 5-Cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine
Purity: ≥98%
Biological Activity
BAY 41-2272 is an activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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NO-independent regulatory site on soluble guanylate cyclase.
Stasch et al.
Nature, 2010;410:212 -
The soluble guanylate cyclase stimulator BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways.
Joshi et al.
J.Pharmacol.Exp.Ther., 2011;339:394 -
Discovery of Riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension.
Mittendorf et al.
ChemMedChem, 2009;4:853
Product Datasheets
Citation for BAY 41-2272
The citations listed below are publications that use Tocris products. Selected citations for BAY 41-2272 include:
1 Citation: Showing 1 - 1
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Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling.
Authors: Aly Et al.
Cell Rep 2019;27:1769-1780.e4
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