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BAY 1816032

Catalog #: 7549 Datasheet
Catalog # Availability Size / Price Qty
7549/10
BAY 1816032 | CAS No. 1891087-61-8 | Checkpoint Control Kinase Inhibitors
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Description: Potent and selective BUB1 kinase inhibitor

Chemical Name: 2-[3,5-Difluoro-4-[[3-[5-methoxy-4-[(3-methoxy-4-pyridinyl)amino]-2-pyrimidinyl]-1H-indazol-1-yl]methyl]phenoxy]ethanol

Purity: ≥98%

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Biological Activity

BAY 1816032 is a potent and selective inhibitor of BUB1 kinase, a mitotic checkpoint serine/threonine kinase (IC50 = 6.1 nM). BAY 1816032 shows 17-fold selectivity over a panel of 403 other human kinases. In vivo, BAY 1816032 decreases tumor size in tumor xenograft models. BAY 181603 is orally bioavailable.

Technical Data

M.Wt:
534.52
Formula:
C27H24F2N6O4
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1891087-61-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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