Bay 11-7821

Biological Activity

Bay 11-7821 is an E2 ubiquitin (Ub) conjugating enzyme inhibitor. Inhibits the conjugation of Ub to a range of E2 enzymes. Inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. Also reversibly activates MAPK signaling. Induces apoptosis of leukemic T cell and B-cell lymphoma cell lines. Also inhibits activation of NLRP3 inflammasome. Binds and inhibits gasdermin D (GSDMD) pore formation. Pyroptosis inhibitor.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome.
   Juliana et al.
   J.Biol.Chem., 2010;285:9792
2. Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells.
   Mori et al.
   Blood, 2002;100:1828
3. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system.
   Strickson et al.
   Biochem.J., 2013;451:427
4. Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo.
   Pierce et al.
   J.Biol.Chem., 1997;272:21096
5. Gasdermin D (GSDMD) as a new target for the treatment of infection.
   Pandeya et al.
   Medchemcomm, 2019;10:660

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