BAM 15
Chemical Name: N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
Purity: ≥98%
Biological Activity
BAM 15 is a mitochondrial protonophore uncoupler; uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). Does not depolarize the plasma membrane. Protects mice from acute renal ischemic-reperfusion injury.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers.
Kenwood et al.
Bioorg.Med.Chem.Lett., 2015;25:4858 -
Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane.
Kenwood et al.
Mol.Metab., 2013;3:114 -
BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control.
Axelrod et al.
EMBO Mol.Med., 2020;:doi: 10.15252
Product Datasheets
Citations for BAM 15
The citations listed below are publications that use Tocris products. Selected citations for BAM 15 include:
3 Citations: Showing 1 - 3
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Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity.
Authors: Panja Et al.
Neuropathol Appl Neurobiol 2019;45:141
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Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility.
Authors: Styr Et al.
Neuron 2019;102:1009
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iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications.
Authors: Wei Et al.
Cell 2018;173:851-863.e16
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