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Balicatib

Catalog #: 5585
1 Citation Datasheet
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5585/50
Balicatib | CAS No. 354813-19-7 | Synthetic Cathepsin Inhibitors
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Description: Potent and selective cathepsin K inhibitor

Chemical Name: N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Balicatib is a potent and selective cathepsin K inhibitor (IC50 values are 1.4, 56 and 480 nM for human, rat and mouse cathepsin K, respectively). Exhibits >300-fold selectivity for cathepsin K over cathepsins L, B and S. Long term supratherapeutic dosing increases tissue levels of cathepsins L and B in rats.

Technical Data

M.Wt:
411.54
Formula:
C23H33N5O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
354813-19-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effect of cathepsin k inhibitor basicity on in vivo off-target activities.
    Desmarais et al.
    Mol.Pharmacol., 2008;73:147

Product Datasheets

Citation for Balicatib

The citations listed below are publications that use Tocris products. Selected citations for Balicatib include:

1 Citation: Showing 1 - 1

  1. Cathepsin K Regulates Intraocular Pressure by Modulating Extracellular Matrix Remodeling and Actin-Bundling in the Trabecular Meshwork Outflow Pathway.
    Authors: Ting Et al.
    Cells  2021;10

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