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AZD 2858

Catalog #: 7650 Datasheet
Catalog # Availability Size / Price Qty
7650/10
7650/50
AZD 2858 | CAS No. 486424-20-8 | Glycogen Synthase Kinase Inhibitors
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Description: Highly potent GSK-3 inhibitor; inhibits tau phosphorylation

Chemical Name: 3-Amino-6-[4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-N-3-pyridinyl-2-pyrazinecarboxamide

Purity: ≥98%

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Biological Activity

AZD 2858 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (IC50 values are 0.9 and 5 nM for GSK-3α and GSK-3β, respectively). AZD 2858 inhibits tau phosphorylation in vitro (IC50 = 76 nM), improves fracture healing and increases bone mass in rodent models of bone fracture. Also activates Wnt signaling in vitro and in vivo. Brain permeable and orally bioavailable.

Technical Data

M.Wt:
453.52
Formula:
C21H23N7O3S
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
486424-20-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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