AZ PFKFB3 67
Chemical Name: (2S)-N-[4-[[3-Cyano-1-[(3,5-dimethyl-4-isoxazolyl)methyl]-1H-indol-5-yl]oxy]phenyl]-2-pyrrolidinecarboxamide
Purity: ≥98%
Biological Activity
AZ PFKFB3 67 is a potent and selective PFKFB3 inhibitor (IC50 values are 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3.
Boyd et al.
J.Med.Chem., 2015;58:3611
Product Datasheets
Citations for AZ PFKFB3 67
The citations listed below are publications that use Tocris products. Selected citations for AZ PFKFB3 67 include:
4 Citations: Showing 1 - 4
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Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition.
Authors: Mihaela Et al.
Nat Metab 2022;4:123-140
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Suppression of myeloid PFKFB3-driven glycolysis protects mice from choroidal neovascularization.
Authors: Zheng Et al.
Br J Pharmacol 2022;179:5109-5131
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PFKFB3-dependent glucose metabolism regulates 3T3-L1 adipocyte development.
Authors: Satoshi Et al.
FASEB J 2021;35:e21728
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LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism.
Authors: Zheng Et al.
EMBO J 2017;36:3325
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