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AZ 13705339

Catalog #: 6177 1 Review Datasheet
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6177/50
AZ 13705339 | CAS No. 2016806-57-6 | PAK Inhibitors
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Description: Highly potent PAK1 and PAK2 inhibitor

Chemical Name: 2-[[[2-[[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylphenyl]amino]methyl]benzonitrile

Purity: ≥98%

Product Details
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AZ 13705339 is a highly potent PAK1 and PAK2 inhibitor (IC50 values are 0.33 and 6 nM for PAK1 and PAK2, respectively). Displays >7500-fold selectivity for PAK1 over PAK4 (IC50 = 2.6 μM).

Technical Data

M.Wt:
629.75
Formula:
C33H36FN7O3S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2016806-57-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Optimization of highly kinase selective bis-anilino pyrimidine PAK1 inhibitors.
    McCoull et al.
    ACS Med.Chem.Lett., 2016;7:1118

Product Datasheets

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Product works well for PAK2 inhibition
By Anonymous on 11/13/2020
Species: Human

10 nM of the compound inhibits the expression of PAK2 protein, assessed by western blotting.

Product works well for PAK2 inhibition 6177
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