AZ 10397767

Catalog #: 5872 Datasheet
Catalog # Availability Size / Price Qty
5872/10
5872/50
AZ 10397767 | CAS No. 333742-63-5 | Chemokine Receptor Antagonists
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Description: Potent CXCR2 antagonist

Chemical Name: 5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one

Purity: ≥98%

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Biological Activity

AZ 10397767 is a potent CXCR2 antagonist (IC50 = 1 nM); attenuates oxaliplatin-induced NF-κB activation, increases oxaliplatin cytotoxicity, and potentiates oxaliplatin-induced apoptosis in AIPC cells. Reduces the numbers of neutrophils infiltrating into tumors in both in vitro and in vivo models and delayed tumor growth. Orally bioavailable.

Technical Data

M.Wt:
400.88
Formula:
C15H14ClFN4O2S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
333742-63-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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