Home / Calcium Binding Protein Modulator Inhibitors / Autocamtide-2-related inhibitory peptide

Autocamtide-2-related inhibitory peptide

Catalog #: 1688
2 Citations Datasheet
Catalog # Availability Size / Price Qty
1688/1
Autocamtide-2-related inhibitory peptide
1 Image
Description: Selective CaM kinase II inhibitor
Alternative Names: AIP

Purity: ≥95%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Autocamtide-2-related inhibitory peptide is a selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor (IC50 = 40 nM). Selective over PKC, PKA and CaM kinase IV (IC50 > 10 μM).

Cell permeable derivative also available.

Technical Data

M.Wt:
1497.76
Formula:
C64H116N22O19
Sequence:
KKALRRQEAVDAL
Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
167114-91-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. The serine/threonine kinase Ndr2 controls integrin trafficking and integrin-dependent neurite growth.
    Rehberg K, Kliche S, Madencioglu D, Thiere M, Muller B, Meineke B, Freund C, Budinger E, Stork O
    J Neurosci, 2014;34(15):5342-54.
  2. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II.
    Ishida et al.
    Biochem.Biophys.Res.Commun., 1995;212:806
  3. Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain.
    Ishida and Fujisawa
    J.Biol.Chem., 1995;270:2163
  4. Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca2+ mobilization.
    Takasawa et al.
    J.Biol.Chem., 1995;270:30257

Product Datasheets

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Citations for Autocamtide-2-related inhibitory peptide

The citations listed below are publications that use Tocris products. Selected citations for Autocamtide-2-related inhibitory peptide include:

2 Citations: Showing 1 - 2

  1. Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit.
    Authors: Cho Et al.
    J Neurosci  2012;32:14165
  2. Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases.
    Authors: Grey and Burrell
    J Neurophysiol  2010;103:2737

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