AP 20187

Biological Activity

AP 20187 is a chemical inducer of dimerization (CID) for use in FKBP fusion protein systems. Induces apoptosis in cells expressing fusion proteins consisting of FKBP^F36V and the intracellular domain of the Fas receptor, Fas-associated death domain (FADD) or a caspase. Selective for FKBP^F36V-Fas fusion proteins over wild-type FKBP. Induces apoptosis of senescent cells expressing caspase-8-FKBP fusion proteins under the control of an Ink4a promoter. Active in vivo.

For more information about how AP 20187 may be used, see our protocol.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins.
   Jacobs et al.
   Nat.Methods, 2018;15:523
2. Adenovirus-mediated transfer of inducible caspases: a novel "death switch" gene therapeutic approach to prostate cancer.
   Shariat et al.
   Cancer Res., 2001;61:2562
3. Naturally occurring p16^Ink4a-positive cells shorten healthy lifespan.
   Baker et al.
   Nature, 2016;530:184
4. Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes.
   Ono
   PLoS One, 2017;12:e0173176

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