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AP 1867

Catalog #: 6207 Datasheet
Catalog # Availability Size / Price Qty
6207/10
6207/50
AP 1867 | CAS No. 195514-23-9 | TAG Degradation Platforms
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Description: Selective binding ligand for FKBP12F36V

Chemical Name: (1R)-1-[3-(Carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl (2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate

Purity: ≥98%

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AP 1867 is a selective binding ligand for the single point mutant of FKBP12F36V (IC50 = 1.8 nM). Functionalized with a carboxylic acid group at the meta-position to enable onward chemistry. The position of the carboxylic acid group represents an 'exit vector' allowing modification without interfering with the compound's binding ability.

Technical Data

M.Wt:
693.79
Formula:
C38H47NO11
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
195514-23-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity.
    Clackson et al.
    Proc.Natl.Acad.Sci.USA., 1998;95:10437

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