Anisomycin
1 Image
Description: JNK, SAPK and p38 activator
Chemical Name: (2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate
Purity: ≥98%
Biological Activity
Anisomycin is a protein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD).Technical Data
M.Wt:
265.31
Formula:
C14H19NO4
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
22862-76-6
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Epigenetic regulation by G9a/GLP complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons
M Sharma, T Dierkes, S Sajikumar
Aging Cell, 2017;0(0):. -
SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
Wang C, Held R, Hall B
PLoS ONE, 2013;8(12):e83941. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun.
Cano et al.
Mol.Cell.Biol., 1994;14:7352 -
The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase.
Croons et al.
J.Pharmacol.Exp.Ther., 2009;329:856 -
Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction.
Hazzalin et al.
Mol.Cell.Biol., 1998;18:1844 -
The stress-activated protein kinase subfamily of c-Jun kinases.
Kyriakis et al.
Nature, 1994;369:156 -
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun.
Sanchez et al.
Nature, 1994;372:794
Product Datasheets
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Citations for Anisomycin
The citations listed below are publications that use Tocris products. Selected citations for Anisomycin include:
21 Citations: Showing 1 - 10
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Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice.
Authors: Beckelman Et al.
J Clin Invest 2019;129:820
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Enhanced Glycolysis Supports Cell Survival in EGFR-Mutant Lung Adenocarcinoma by Inhibiting Autophagy-Mediated EGFR Degradation.
Authors: Kim Et al.
Cancer Res 2018;78:4482
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Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer's disease.
Authors: Li
Proc Natl Acad Sci U.S.A. 2017;114(21):5527
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Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus.
Authors: Zhao Et al.
Neurobiol Dis 2015;35:308
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Direct visualization of newly synthesized target proteins in situ.
Authors: Dieck Et al.
Nat Methods 2015;12:411
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SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
Authors: Wang Et al.
PLoS One 2014;8:e83941
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Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.
Authors: Dobrikov Et al.
Mol Cell Biol 2014;34:439
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Small molecule screen yields inhibitors of Pseudomonas homoserine lactone-induced host responses.
Authors: Valentine Et al.
Cell Microbiol 2014;16:1
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Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells.
Authors: Basu Et al.
Autophagy 2014;10:1193
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Long lasting protein synthesis- and activity-dependent spine shrinkage and elimination after synaptic depression.
Authors: Ramiro-Cortés
PLoS One 2013;8:e71155
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Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
Authors: Bernard Et al.
Autophagy 2013;59:42736
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Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.
Authors: Ma Et al.
Nat Neurosci 2013;16:1299
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Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings.
Authors: Liu Et al.
J Neurophysiol 2013;110:505
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Metabolic labeling with noncanonical amino acids and visualization by chemoselective fluorescent tagging.
Authors: Dieck Et al.
Curr Protoc Cell Biol 2012;Chapter 7:Unit7.11
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On the mechanism of synaptic depression induced by CaMKIIN, an endogenous inhibitor of CaMKII.
Authors: Gouet Et al.
PLoS One 2012;7:e49293
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Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.
Authors: Fortin Et al.
J Neurosci 2012;32:8127
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Dual regulation of fragile X mental retardation protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus.
Authors: Zhao Et al.
J Neurosci 2011;31:725
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Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry.
Authors: Hays Et al.
J Neurosci 2011;31:14223
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Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation.
Authors: Fuortes Et al.
Epilepsia 2010;51:1633
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Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
Authors: Huang Et al.
J Neurosci 2010;30:6080
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BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability.
Authors: Zhong Et al.
J Neurosci 2009;29:9977
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Increase p38 MAPK activity
By Anonymous
on 11/02/2017
We use anisomycin to increrase p38 MAPK activity, though it can also be used to block protein synthesis.
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