Ani 9
Chemical Name: 2-(4-Chloro-2-methylphenoxy)-N'-(2-methoxybenzylidene)acetohydrazide
Purity: ≥98%
Biological Activity
Ani 9 is a potent and selective TMEM16A (Anoctamin-1; ANO1) blocker (IC50 = 77 nM). Displays no effect on ANO2 activity (at 10 μM). Also exhibits no effect on intracellular calcium signaling or CFTR and ENaC channel activity (at 30 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Ani9, a novel potent small-molecule ANO1 inhibitor with negligible effect on ANO2.
Seo et al.
PLoS One, 2016;11:e0155771
Product Datasheets
Citations for Ani 9
The citations listed below are publications that use Tocris products. Selected citations for Ani 9 include:
2 Citations: Showing 1 - 2
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The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells
Authors: Dwivedi Et al.
Eur J Pharmacol 2023;
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ANO1 Expression Orchestrates p27Kip1/MCL1-Mediated Signaling in Head and Neck Squamous Cell Carcinoma.
Authors: Heikki Et al.
Cancers (Basel) 2021;13
FAQs
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