Anacardic acid

Biological Activity

Anacardic acid is a noncompetitive inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC₅₀ values are ~5.0 and ~8.5 μM respectively). Inhibits NF-κB activation. Also reported to selectively activate Aurora kinase A-mediated phosphorylation of histone H3 and to inhibit protein SUMOylation. Exhibits antitumor, antimicrobial and antioxidant activity. Also promotes cardiomyocyte differentiation from mESCs.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Small molecule modulators of histone acetyltransferase p300.
   Balasubramanyam et al.
   J.Biol.Chem., 2003;278:19134
2. Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate.
   Fukuda et al.
   Chem.Biol., 2009;16:133
3. Specific small molecule activator of aurora kinase A induces autophosphorylation in a cell-free system.
   Kishore et al.
   J.Med.Chem., 2008;51:792
4. Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the
   Sung et al.
   Blood, 2008;111:4880
5. Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development.
   Cui et al.
   Eurkaryot.Cell, 2008;7:1200
6. Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas
   
   Stem Cell Reports, 2016;0(0):.
7. Anacardic acid and thyroid hormone enhance cardiomyocytes production from undifferentiated mouse ES cells along functionally distinct pathways.
   Re et al.
   Endocrine, 2016;53:681

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