Amphotericin B
Chemical Name: (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
Purity: ≥90%
Biological Activity
Amphotericin B forms nonselective monovalent ion channels within lipid bilayers. Amphotericin B binds ergosterol in the cell membrane. Antifungal and antiprotozoal.For more information about how Amphotericin B may be used, see our protocol:
3D Culture of Lung Alveolar CellsTechnical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia.
Muruglia et al.
Nature., 2019;567:405 -
Amphotericin B: 30 years of clinical experience.
Gallis et al.
Rev.Infect.Dis., 1990;12:308 -
Current concepts in antifungal pharmacology.
Lewis
Mayo Clin.Proc., 2011;86:805
Product Datasheets
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